摘要
大豆素(大豆苷元)属于异黄酮类植物雌激素,具有抗氧化、抗应激、促生长等作用。近年来,研究发现大豆素还可影响动物的脂代谢,但研究相对较少。本文就大豆素的理化性质、吸收与代谢形式、对动物脂代谢的影响及作用机理的研究进展作一综述。
引文
[1]占今舜,王冰,胡金杰,等.大豆黄酮作为饲料添加剂的应用前景.粮食与饲料工业,2013,7:44-46.
[2]Franke A A,Custer L J,Cerna C M,et al..Quantitation of phytoestrogens in legumes by HPLC.Journal of Agricultural and Food Chemistry,1994,42(9):1905-1913.
[3]Virgilio A L D,Iwami K,Watjen W,et al..Genotoxicity of the isoflavones genistein,daidzein and equol in V79 cells.Toxicology Letters,2004,151(1):151-162.
[4]Faqi A S,Johnson W D.Morrissey R L,et al..Reproductive toxicity assessment of chronic dietary exposure to soy isoflavones in male rats.Reproductive Toxicology,2004,18(4):605-611.
[5]Lamartiniere C,Wang J,Smith-Johnson M,et al..Daidzein:bioavailability,potential for reproductive toxicity,and breast cancer chemoprevention in female rats.Toxicological Sciences,2002,65(2):228-238.
[6]Ibarreta D,Daxenberger A,Meyer H H.Possible health impact of phytoestrogens and xenoestrogens in food.Apmis,2001,109(S103):S402-S425.
[7]Piskula M K,Yamakoshi J,Iwai Y.Daidzein and genistein but not their glucosides are absorbed from the rat stomach.FEBS Letters,1999,447(2):287-291.
[8]Izumi T,Piskula M K,Osawa S,et al..Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans.The Journal of Nutrition,2000,130(7):1695-1699.
[9]Day A J,Dupont M S,Ridley S,et al..Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liverβ-glucosidase activity.FEBS Letters,1998,436(1):71-75.
[10]Nemeth K,Plumb G W,Berrin J G,et al..Deglycosylation by small intestinal epithelial cellβ-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.European Journal of Nutrition,2003,42(1):29-42.
[11]Bowey E,Adlercreutz H,Rowland I.Metabolism of isoflavones and lignans by the gut microfloras study in germfree and human flora associated rats.Food and Chemical Toxicology,2003,41(5):631-636.
[12]Wilkinson A,Gee J,Dupont M,et al..Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro.Xenobiotica,2003,33(3):255-264.
[13]Setchell K D,Brown N M.Zimmer-Nechemias L.et al..Evidence for lack of absorption of soy isoflavone glycosides in humans,supporting the crucial role of intestinal metabolism for bioavailability.The American Journal of Clinical Nutrition,2002,76(2):447-453.
[14]LUNDH T.Metabolism of estrogenic isoflavones in domestic animals.Experimental Biology and Medicine,1995,208:33-39.
[15]Lundh T J,Pettersson H I,Martinsson K A.Comparative levels of free and conjugated plant estrogens in blood plasma of sheep and cattle fed estrogenic silage.Journal of Agricultural and Food Chemistry,1990,38(7):1530-1534.
[16]Cho K W,Lee O H,Banz W J,et al..Daidzein and the daidzein metabolite,equol,enhance adipocyte differentiation and PPARγtranscriptional activity.The Journal of Nutritional Biochemistry,2010,21(9):841-847.
[17]Nishide Y,Tousen Y,Inada M,et al..Bi-phasic effect of equol on adipocyte differentiation of MC3T3-L1 cells.Bioscience,Biotechnology,and Biochemistry,2013,77(1):201-204.
[18]Hirota K,Morikawa K,Hanada H,et al..Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line.Journal of Agricultural and Food Chemistry,2010,58(9):5821-5827.
[19]Sakamoto Y,Naka A,Ohara N,et al..Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPARy.Molecular Nutrition&Food Research,2014,58(4):718-726.
[20]Liu D,Zhen W,Yang Z,et al..Genistein acutely stimulates insulin secretion in pancreaticβ-cells through a cAMP-dependent protein kinase pathway.Diabetes,2006,55(4):1043-1050.
[21]Li F,Li L,Yang H,et al..Regulation of soy isoflavones on weight gain and fat percentage:evaluation in a Chinese Guangxi minipig model.Animal,2011,5(12):1903-1908.
[22]Rehfeldt C,Adamovic I,Kuhn G.Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny.Meat Science,2007,75(1):103-111.
[23]Zhao X H,Yang Z Q,Bao L B,et al..Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers.Experimental Biology and Medicine,2015,240:1152-1157.
[24]Szkudelska K,Szkudelski T,Nogowski L.Daidzein,coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes.Phytomedicine,2002,9(4):338-345.
[25]Choi M S,Jung U J,Kim M J,et al..Effect of Genistein and Daidzein on Glucose Uptake in Isolated Rat Adipocytes;Comparison with Respective Glycones.Journal of Food Science and Nutrition,2005,10(1):52-57.
[26]Kim M H,Park J S,Seo M S,et al..Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis.Cell Proliferation,2010,43(6):594-605.
[27]Cao Y,Zhang S,Zou S,et al..Daidzein improves insulin resistance in ovariectomized rats.Climacteric,2013,16(1):111-116.
[28]Rachon D,Vortherms T,Seidlova-Wuttke D,et al..Effects of dietary equol on body weight gain,intra-abdominal fat accumulation,plasma lipids,and glucose tolerance in ovariectomized Sprague-Dawley rats.Menopause,2007,14(5):925-932.
[29]刘皙洁,张桂春,张维生.半胱胺、大豆黄酮对肉仔鸡脂肪代谢的影响.东北农业大学学报,2003,34(2):210-218.
[30]Sosic-Jurjevicb,Filipovicb,Ajdzanovicv,et al..Subcutaneously administrated genistein and daidzein decrease serum cholesterol and increase triglyceride levels in male middle-aged rats.Experimental Biology and Medicine,2007,232(9):1222-1227.
[31]Dang Z,L(o|¨)wik C W.The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis.Journal of Bone and Mineral Research,2004,19(5):853-861.
[32]Ra A,Zand-Moghaddam A.Effects of soy protein isoflavones on serum lipids,lipoprotein profile and serum glucose of hypercholesterolemic rabbits.International Journal of Endocrinology and Metabolism,2005,2:87-92.
[33]Burns T.Fatty acids and lipogenesis in ruminant adipocytes.Doctoral dissertation,Clemson University.2011.
[34]De Jager N,Hudson N,Reverter A,et al..Gene expression phenotypes for lipid metabolism and intramuscular fat in skeletal muscle of cattle.Journal of Animal Science,2013,91(3):1112-1128.
[35]Bonnet M,Faulconnier Y,Leroux C,et al..Glucose-6-phosphate dehydrogenase and leptin are related to marbling differences among Limousin and Angus or Japanese BlackX Angus steers.Journal of Animal Science,2007,85(11):2882-2894.
[36]Lee Y,Oh D,Lee J,et al..Novel single nucleotide polymorphisms of bovine SREBP1 gene is association with fatty acid composition and marbling score in commercial Korean cattle(Hanwoo).Molecular Biology Reports,2013,40(1):247-254.
[37]Hoashi S,Hinenoya T,Tanaka A,et al..Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese Black cattle.BMC Genetics,2008,9(1):84-90.
[38]Shin S C,Heo J P,Chung E R.Genetic variants of the FABP4 gene are associated with marbling scores and meat quality grades in Hanwoo(Korean cattle).Molecular Biology Reports,2012,39(5):5323-5330.
[39]Jurie C,Cassar-Malek I,Bonnet M,et al..Adipocyte fatty acid-binding protein and mitochondrial enzyme activities in muscles as relevant indicators of marbling in cattle.Journal of Animal Science,2007,85(10):2660-2669.
[40]Brown J D,Plutzky J.Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets.Circulation,2007,115(4):518-533.
[41]Rangwala S M,Lazar M A.Peroxisome proliferator-activated receptor y in diabetes and metabolism.Trends in Pharmacological Sciences,2004,25(6):331-336.
[42]Moisa S J.Shike D W,Faulkner D B,et al..Central Role of the PPARy Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition.Gene Regulation and Systems Biology,2014,8:17-32.
[43]Ahmadian M,Suh J M,Hah N,et al..PPAR gamma signaling and metabolism:the good,the bad and the future.Nature Medicine,2013,99(5):557-566.
[44]Gandhi G R,Stalin A,Balakrishna K,et al..Insulin sensitization via partial agonism of PPARy and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats.Biochimica et Biophysica Acta(BBA)-General Subjects,2013,1830(1):2243-2255.
[45]Barak Y,Nelson M C.Ong E S,et al..PPARy is required for placental,cardiac,and adipose tissue development.Molecular Cell,1999,4(4):585-595.
[46]Moldes M,Zuo Y,Morrison R,et al..Peroxisome-proliferator-activated receptor y suppresses Wnt/β-catenin signalling during adipogenesis.Biochemical Journal,2003,376:607-613.
[47]Mueller M,Jungbauer A.Red clover extracts putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome.Menopause,2008,15(6):1120-1131.
[48]Ricketts M L,Moore D D.Banz W J,et al..Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors.A review.The Journal of Nutritional biochemistry,2005,16(6):321-330.
[49]Mezei O,Banz W J,Steger R W,et al..Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells.The Journal of Nutrition,2003,133(5):1238-1243.
[50]Hurtado O,Ballesteros I,Cuartero M,et al..Daidzein has neuroprotective effects through ligand-binding-independent PPARy activation.Neurochemistry international,2012,61(1):119-127.
[51]Chacko B K,Chandler R T.D'alessandro T L,et al..Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARy.The Journal of Nutrition,2007,137(2):351-356.
[52]Cho K W,Kim K O,Burgess J R,et al..Daidzein stimulates glucose uptake through activation of PPAR gamma in3T3-L1 adipocytes.The FASEB Journal,2006,20(4):A597.
[53]Park H J,Della-Fera M A.Hausman D B,et al..Genistein inhibits differentiation of primary human adipocytes.The Journal of Nutritional Biochemistry,2009,20(2):140-148.
[54]Deroo B J,Korach K S.Estrogen receptors and human disease.The Journal of Clinical Investigation,2006,116(3):561-570.
[55]Cooke P S.Heine P A,Taylor J A,et al..The role of estrogen and estrogen receptor-o in male adipose tissue.Molecular and Cellular Endocrinology,2001,178(1):147-154.
[56]Wend K,Wend P.Drew B G,et al..ERa regulates lipid metabolism in bone through ATGL and perilipin.Journal of Cellular Biochemistry,2013,114(6):1306-1314.
[57]Foryst-Ludwig A.Clemenz M.Hohmann S,et al..Metabolic actions of estrogen receptor beta(ERβ)are mediated by a negative cross-talk with PPARy.PLoS Genet,2008,4(6):e1000108.
[58]Dang Z C,Audinot V,Papapoulos S E,et al..Peroxisome proliferator-activated receptorγ(PPARγ)as a molecular target for the soy phytoestrogen genistein.Journal of Biological Chemistry,2003,278(2);962-967.