太极拳对不同性别2型糖尿病患者治疗效果的比较研究
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摘要
探讨太极拳健康干预对不同性别2型糖尿病患者治疗效果的差异性.招募2型糖尿病患者40例,其中男20例,女20例,均进行太极拳练习8周,每周5d,每天2次,每次60min.主要疗效指标包括空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)、空腹胰岛素水平(FINS)、胰岛素抵抗(HOMA-IR)以及胰岛素敏感性(ISI);次要疗效指标包括高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三脂(TG)、总胆固醇(TC)、体质量指数(BMI)、血压(BP)、生活品质(GQOL-74).干预8周后,各项指标变化为:糖代谢指标,男女2组FBG、HbA1c以及HOMA-IR均非常显著性下降(P<0.01),2hPBG均显著性下降(P<0.05),但FBG及2hPBG下降幅度男性组显著性大于女性组(P<0.05),ISI均非常显著性升高(P<0.01);脂代谢指标,男女2组TG及BMI均非常显著性下降(P<0.01),其他指标差异无显著性(P>0.05);生活品质,男女2组心理功能均得到显著性提高(P<0.05),男性组躯体功能的改善显著性高于女性组(P<0.05),女性组社会功能的改善显著性高于男性组(P<0.05).8周太极拳练习作为辅助治疗手段,可以改善T2DM患者糖脂代谢水平以及提高其生活品质,其中男性组治疗效果优于女性组,其机制值得进一步研究.
The effect of Tai Chi health intervention on the treatment effects of patients with type 2 diabetes was examined.A total of 40 type 2 diabetes patients were recruited,20 patients for each sex.All patients did Tai Chi exercises for 8 weeks,5 days a week,twice a day each session lasting for 60 min.Main clinical parameters examined were fasting blood glucose(FBG),2-hour postmeal blood glucose(2 hPBG),glycosylated hemoglobin(HbA1 c),fasting insulin level(FINS),insulin resistance(HOMA-IR)and insulin-sensitive(ISI)Other parameters examined were high density lipoprotein(HDL),low density lipoprotein(LDL),triglyceride(TG),total cholesterol(TC),body mass index(BMI),blood pressure(BP)and quality of life(GQOL-74).After 8 weeks of Tai Chi intervention,FBG,HbA1 cand HOMA-IR decreased significantly and 2 hPBG decreased significantly in both sex,but decrease in FBG and 2 hPBG in men was significantly higher than in women(P<0.05).ISI significantly increased(P<0.01).After 8 weeks of intervention,TG and BMI in both groups decreased significantly(P<0.01),but no significant difference was found between men and women in other indexes.After 8 weeks of intervention,the psychological function of both groups significantly improved(P<0.05),improvement in physical function in men was significantly higher than that in women(P<0.05).Improvement in social function in women was significantly higher than in men(P<0.05).It is concluded that8-week Tai Chi exercise improved glycolipid metabolism in patients with T2 DM and improved quality of life in patients with T2 DM The treatment effect in men was superior to women,the mechanism for this difference is worthy of further study.
The effect of Tai Chi health intervention on the treatment effects of patients with type 2 diabetes was examined.A total of 40 type 2 diabetes patients were recruited,20 patients for each sex.All patients did Tai Chi exercises for 8 weeks,5 days a week,twice a day each session lasting for 60 min.Main clinical parameters examined were fasting blood glucose(FBG),2-hour postmeal blood glucose(2 hPBG),glycosylated hemoglobin(HbA1 c),fasting insulin level(FINS),insulin resistance(HOMA-IR)and insulin-sensitive(ISI)Other parameters examined were high density lipoprotein(HDL),low density lipoprotein(LDL),triglyceride(TG),total cholesterol(TC),body mass index(BMI),blood pressure(BP)and quality of life(GQOL-74).After 8 weeks of Tai Chi intervention,FBG,HbA1 cand HOMA-IR decreased significantly and 2 hPBG decreased significantly in both sex,but decrease in FBG and 2 hPBG in men was significantly higher than in women(P<0.05).ISI significantly increased(P<0.01).After 8 weeks of intervention,TG and BMI in both groups decreased significantly(P<0.01),but no significant difference was found between men and women in other indexes.After 8 weeks of intervention,the psychological function of both groups significantly improved(P<0.05),improvement in physical function in men was significantly higher than that in women(P<0.05).Improvement in social function in women was significantly higher than in men(P<0.05).It is concluded that8-week Tai Chi exercise improved glycolipid metabolism in patients with T2 DM and improved quality of life in patients with T2 DM The treatment effect in men was superior to women,the mechanism for this difference is worthy of further study.
引文
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[12]孟晴，陈伟，张明，等．有氧联合抗阻运动对2型糖尿病患者的效果[J]．中国康复理论与实践，2018,24(12):1465
[13]沈文清，孙易，漆正堂，等．运动结合二甲双胍对2型糖尿病血糖稳态的作用及其可能机制研究进展[J]．体育学刊，2018,25(6):137
[14]WINNICK J J,SHERMAN W M,HABASH D L,et al.Cardiovascular effects of intensive lifestyle intervention in type 2diabetes[J].N Engl J Med,2013,369(2):145
[15]DUNSTAN D W,DALY R M,OWEN N,et al.High-intensity resistance training improves glycemic control in older patients with type 2diabetes[J].Diabetes Care,2002,25(10):1729
[16]朱欢，覃林，李荣娟，等．24式太极拳运动对老年2型糖尿病患者的疗效[J]．中国老年学杂志，2017,37(3):737
[17]张迎军，陈明坤．太极拳对中老年人血脂及肥胖II型糖尿病的调节作用[J]．北京体育大学学报，2008(5):625
[18]蒙恩．太极拳运动对2型糖尿病患者血脂成分及胰岛素抵抗的影响[J]．中国老年学杂志，2014,34(19):5358
[2]HAFFNER S M,VALDEZ R A,HAZUDA H P,et al.Prospective analysis of the insulin-resistance syndrome(syndrome X)[J].Diabetes,1992,41(6):715
[3]WACHINO J,DOI Y,YAMANE K,et al.Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase,GES-4,possessing a single G170Ssubstitution in the omega-loop[J].Antimicrob Agents Chemother,2004,48(8):2905
[4]汪向东，王希林，马弘．心理卫生评定量表手册[M]．增订版．北京：中国心理卫生杂志社，1999:73-81
[5]COIMBRA S,REIS F,NUNES S,et al.The protective role of adiponectin for lipoproteins in end-stage renal disease patients:relationship with diabetes and body mass index[J/OL].Oxidative Medicine and Cellular Longevity,2019:1[2019-03-20].http：∥doi.org/10.1155/2019/3021785
[6]MANSON J E,RIMM E B,STAMPFER M J,et al.Physical activity and incidence of non-insulin-dependent diabetes mellitus in women[J].Lancet,1991,338(8770):774
[7]KNOWLER W C,LEWIS C E,MASCHAK B J,et al.Cardiovascular effects of intensive lifestyle intervention in type 2diabetes[J].N Engl J Med,2013,369(2):145
[8]王炜，叶山东，钱立庭，等．新诊断2型糖尿病患者血清维生素D与胰岛素抵抗及胰岛β细胞功能的相关性研究[J]．中国糖尿病杂志，2018,26(10):802
[9]张程昌，潘佳秋，刘文文，等．新诊断2型糖尿病患者血清丝氨酸蛋白酶抑制剂B1水平与胰岛素抵抗的相关性研究[J]．中国糖尿病杂志，2018,26(10):821
[10]WEYER C,FUNAHASHI T,TANAKA S,et al.Hypoadiponectinemia in obesity and type 2 diabetes:close association with insulin resistance and hyperinsulinemia[J].Clin Endocrinol Metab,2001,86(5):1930
[11]靳俊，郁磊，靳祯．不同强度有氧运动下糖尿病患者血糖代谢模型仿真研究[J]．生物医学工程学杂志，2019,36(2):274
[12]孟晴，陈伟，张明，等．有氧联合抗阻运动对2型糖尿病患者的效果[J]．中国康复理论与实践，2018,24(12):1465
[13]沈文清，孙易，漆正堂，等．运动结合二甲双胍对2型糖尿病血糖稳态的作用及其可能机制研究进展[J]．体育学刊，2018,25(6):137
[14]WINNICK J J,SHERMAN W M,HABASH D L,et al.Cardiovascular effects of intensive lifestyle intervention in type 2diabetes[J].N Engl J Med,2013,369(2):145
[15]DUNSTAN D W,DALY R M,OWEN N,et al.High-intensity resistance training improves glycemic control in older patients with type 2diabetes[J].Diabetes Care,2002,25(10):1729
[16]朱欢，覃林，李荣娟，等．24式太极拳运动对老年2型糖尿病患者的疗效[J]．中国老年学杂志，2017,37(3):737
[17]张迎军，陈明坤．太极拳对中老年人血脂及肥胖II型糖尿病的调节作用[J]．北京体育大学学报，2008(5):625
[18]蒙恩．太极拳运动对2型糖尿病患者血脂成分及胰岛素抵抗的影响[J]．中国老年学杂志，2014,34(19):5358