The Middle and Lower Reaches of the Yangtze River is a typical area where the tectonic system converted from Mesozoic Tethys tectonic regime to the Pacific tectonic regime. The structural knots of the Middle and Lower Reaches of Yangtze River were the result of tectonic regime transition between Tethys and Pacific tectonic regimes in eastern China, Dabie Orogenic belt, Tan-Lu Faulting belt, and Middle-Lower Reaches of Yangtze River metallogenic belts directly recorded the transition process of the two tectonic regimes, spatial-temporal relations between deposition-tectonic-magmatic-metallogenic and dynamic setting. Therefore, the intersection positions between various-scale NE-SW trending structural belts and NW-SE trending structural belts are the locations of ore concentration areas and important deposits.