Since 1990s, there has been serious karst surface-collapse geological disaster in Chini Town Huadu area of Guangzhou. Based on exploration data on the spot, this paper analyzes the distribution and development features of karst surface-collapse in Chini Town systematically. Studies show that the main cause of the collapse is artificial formation of negative terrain quarry excavation and excessive pumping of groundwater. On this basis, in accordance with the reality of Chini Town karst surface-collapse, the authors put forward some countermeasure about prevent karst surface-collapse.