Gongguan-Qingtonggou Hg-Sb deposit in Xunyang, Shaanxi Province is controlled by both strata and faults, and ore bodies occur in the faults at each level in the dolomite of the Devonian Gongguan Formation. Hydrogen and oxygen isotopic study indicates that the ore-forming fluid is dominated by meteoric water. Carbon and oxygen isotopes reveal that the formation of hydrothermal calcite is closely related to the strata. The carbon isotope composition of the hydrothermal calcite is not completely consistent with that of ore-bearing strata due to the organic carbon in the strata mixed with the ore-forming fluid.