The Tianqiao Pb—Zn ore deposit, Hezhang County, is located in the southwest of the Yangtze craton, the center of the Northwestern Guizhou Pb—Zn metallogenic province. This paper analyzes the sulfur and lead isotopic compositions and REE contents of these ore-bodies. The data show that the ore minerals in these ore-bodies are enriched in heavy sulfur. On the chondrite-normalized REE patterns, the characteristics of sulfides are accord with the patterns of ores, altered dolostone rock, strata and the pyrite form C1d (the Datang Fm.), which indicate that the ore-forming fluids maybe come from polycomponenet system, the different chronostratigraphic units maybe make an important contribution together, this accord with the S and Pb isotopes’ result, that is the ore-forming fluids and ore-forming metals are poly-sources.