The type of weathering experienced in Gaoyou Depression of North Jiangsu Basin was mainly physical weathering. In this paper, the authors deduce that the majority of source rocks in studied area come from denuded original basement and recycling sedimentary deposits. Geochemical data display that the tectonic setting of studied area is included in the Andean-type continental margin. The authors deem that this tectonic setting of North Jiangsu Basin reflects a special tectonics of East China and is differed to the typical Andean active continental margin of the eastern Pacific Ocean, for the big divergence between these two regions no matter in geologic history or in dynamic mechanism.