There existed visible lateral variations of the Jinning Period and Caledonian structural lineaments in middle-southern Hunan Province. The Jinning Period and Caledonian structural lineaments in Tongdao-Xupu-Anhua-Taojiang area showed an arc bulging to northwest. Combined with regional compressional stress field, the trend of the boundaries can be taken to explain the dynamic mechanisms of the lateral changes of Jinning Period and Caledonian structural lineaments.