By analyzing the hydrocarbon accumulation conditions under the guideline of sequence stratigraphy, the hydrocarbon accumulation mechanism in the low permeability, tight reservoirs of the Yanchang Formation in the Ordos Basin is studied from the perspective of pore evolution, and the hydrocarbon accumulation evolution models are concluded. The low permeability, tight reservoirs of the Yanchang Formation are distributed within the range of good hydrocarbon source rocks. The reservoir sand-bodies are dominated by lacustrine gravity flow deposits and delta front deposits. In the early period when hydrocarbons are accumulated in the Yanchang Formation, the reservoirs are characterized by high porosity and high permeability. The oil and gas generated in the period are accumulated normally under the effect of buoyancy. In the middle-late period, the reservoirs have experienced continuous compression. The petroleum generated in the late period, the major hydrocarbon generation period, migrates and accumulates by infiltration along the previously remained paths under the effect of buoyancy and pressure difference between the source rocks and the reservoirs. When the reservoirs become tight, oil and gas stop migration. From the Late Jurassic to the middle period of the Early Cretaceous, oil and gas widely charge the high porosity sandstones near the source rocks when they migrate from the center of the lacustrine basin to the borders. In the late period of the Early Cretaceous, the diagenesis of sandstone reservoirs is enhanced, making the reservoirs tight. After the Late Cretaceous, the present low permeability tight lithologic reservoirs are formed due to the compressing and uplifing movement of the structure which dips down in the west and tilts up in the east.