Green Oxidation Process in the Synthesis of LLM-105 with H₂O₂/Peroxotungstate System and its Theoretical Study

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• 作者：Jie Zhu ; Xue-Jing Zhao ; Peng-Cheng Wang and Ming Lu
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：53
• 期：5
• 页码：1386-1394
• 全文大小：2064K
• ISSN：1943-5193

文摘

A new catalytic system was developed and applied to the pan class="TH_term4">oxidation reactionspan> involved in the synthesis of , in which protonated peroxotungstate combining chitosan was used as catalyst. With H₂O₂ as oxidant, good to excellent yields could be achieved in the synthesis of pan class="TH_term3">pyrazine-1-oxidepan>, pan class="TH_term3">2,6-dimethoxypyrazine-1-oxidepan>, pan class="TH_term3">2,6-dichloropyrazine-1-oxidepan>, and pan class="TH_term3">2-chloro-6-methoxypyrazine-1-oxidepan> without any addition of pan class="TH_term1 TH_term3">trifluoracetic acidpan>, which provided a significant exploration toward novel and environmentally benign synthetic route for . Theoretical studies were also carried out with Gaussian 03 to evaluate the oxidation process. All of the calculated data matched well with our experimental results.