Neurological mechanism of Xiaochaihutang's antidepressant-like effects to socially isolated adult rats

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• 作者：Jie Ma ; Chun Fu Wu ; Fang Wang ; Jing Yu Yang ; Ying Xu Dong ; Guang Yue Su ; Kuo Zhang ; Zhi Qian Wang ; Long Wen Xu ; Xing Pan ; Ting Shuo Zhou ; Ping Ma and Shao Jiang Song
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：68
• 期：10
• 页码：1340-1349
• 全文大小：829K
• ISSN：2042-7158

文摘

Xiaochaihutang (XCHT) has antidepressant effects in multiple animal models of depression in our previous studies. But the antidepressant effects and exact mechanisms of XCHT in a rat model of chronic social isolation stress (CSIS) have never been studied. We therefore aimed to investigate the effects of XCHT on depressive/anxiety-related behaviours of CSIS-exposed rats and understand the neurological mechanism involving neurogenesis.