Evidence for altered cholesterol metabolism in Huntington's disease post mortem brain tissue

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• 作者：Fabian Kreilaus ; Adena S. Spiro ; Catriona A. McLean ; Brett Garner and Andrew M. Jenner
• 刊名：Neuropathology and Applied Neurobiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：42
• 期：6
• 页码：535-546
• 全文大小：2860K
• ISSN：1365-2990

文摘

Cholesterol plays an essential role in membrane structure and function, being especially important in the brain. Alteration of brain cholesterol synthesis and metabolism has been demonstrated in several Huntington's disease (HD) mouse and cell models; however, less is known about these alterations in human tissue. This study aimed to identify alterations to cholesterol synthetic and metabolic pathways in human HD brain tissue.