Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis

详细信息    查看全文

• 作者：Huanxing Sun ; Yangyang Zhu ; Hongyi Pan ; Xiaosong Chen ; Jenna L. Balestrini ; TuKiet T. Lam ; Jean E. Kanyo ; Anne Eichmann ; Mridu Gulati ; Wassim H. Fares ; Hanwen Bai ; Carol A. Feghali-Bostwick ; Ye Gan ; Xueyan Peng ; Meagan W. Moore ; Eric S. White ; Parid Sava ; Anjelica L. Gonzalez ; Yuwei Cheng ; Laura E. Niklason and Erica L. Herzog
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：68
• 期：5
• 页码：1251-1261
• 全文大小：521K
• ISSN：1529-0131

文摘

Fibrocytes are collagen-producing leukocytes that accumulate in patients with systemic sclerosis (SSc; scleroderma)–related interstitial lung disease (ILD) via unknown mechanisms that have been associated with altered expression of neuroimmune proteins. The extracellular matrix (ECM) influences cellular phenotypes. However, a relationship between the lung ECM and fibrocytes in SSc has not been explored. The aim of this study was to use a novel translational platform based on decellularized human lungs to determine whether the lung ECM of patients with scleroderma controls the development of fibrocytes from peripheral blood mononuclear cells.