In vivo biological response to highly cross-linked and vitamin e-doped polyethylene—a particle-Induced osteolysis animal study

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• 作者：Chang-Hung Huang ; Yung-Chang Lu ; Ting-Kuo Chang ; I-Lin Hsiao ; Yi-Ching Su ; Shu-Ting Yeh ; Hsu-Wei Fang and Chun-Hsiung Huang
• 关键词：osteolysis ; polyethylene ; particulate debris ; cross-linked ; antioxidant
• 刊名：Journal of Biomedical Materials Research Part B: Applied Biomaterials
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：104
• 期：3
• 页码：561-567
• 全文大小：412K
• ISSN：1552-4981

文摘

Polyethylene particle-induced osteolysis is the primary limitation in the long-term success of total joint replacement with conventional ultra high molecular weight polyethylene (UHMWPE). Highly cross-linked polyethylene (HXLPE) and vitamin E-doped cross-linked polyethylene (VE-HXLPE) have been developed to increase the wear resistance of joint surfaces. However, very few studies have reported on the incidence of particle-induced osteolysis for these novel materials. The aim of this study was to use a particle-induced osteolysis animal model to compare the in vivo biological response to different polymer particles. Three commercially available polymers (UHMWPE, HXLPE, and VE-HXLPE) were compared. Osseous properties including the bone volume relative to the tissue volume (BV/TV), trabecular thickness (Tb. Th), and bone mineral density (BMD) were examined using micro computed tomography. Histological analysis was used to observe tissue inflammation in each group. This study demonstrated that the osseous properties and noticeable inflammatory reactions were obviously decreased in the HXLPE group. When compared with the sham group, a decrease of 12.7% was found in BV/TV, 9.6% in BMD and 8.3% in Tb.Th for the HXLPE group. The heightened inflammatory response in the HXLPE group could be due to its smaller size and greater amount of implanted particles. Vitamin E diffused in vivo may not affect the inflammatory and osteolytic responses in this model. The morphological size and total cumulative amount of implanted particles could be critical factors in determining the biological response.