Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas

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• 作者：Wei-Ming Li ; Yu-Ching Wei ; Chun-Nung Huang ; Hung-Lung Ke ; Ching-Chia Li ; Hsin-Chih Yeh ; Lin-Li Chang ; Chun-Hsiung Huang ; Chien-Feng Li and Wen-Jeng Wu
• 关键词：MMP-11 ; urothelial carcinoma ; bladder cancer ; upper urinary tract urothelial carcinoma ; prognosis
• 刊名：Journal of Surgical Oncology
• 出版年：2016
• 出版时间：May 1, 2016
• 年：2016
• 卷：113
• 期：6
• 页码：700-707
• 全文大小：695K
• ISSN：1096-9098

文摘

Urothelial carcinomas (UC) of urinary bladder (UB) and upper urinary tract (UT) are heterogeneous diseases with high morbidity and mortality. We looked for genes with metalloendopeptidase activity in a published UBUC transcriptomic database (GSE31684):MMP-11 was the most significant, showing stepwise up-regulation. We analyzed MMP-11 expression and association with clinicopathologic factors and survival in our well-characterized cohort of UCs.