ChemInform Abstract: Synthetic and Theoretical Investigation on the One-Pot Halogenation of β-Amino Alcohols and Nucleophilic Ring Opening of Aziridinium Ions.
A variety of optically active secondary N,N-disubstituted β-halo amines are efficiently synthesized from N,N-disubstituted alaninol via formation and ring opening (at the more hindered carbon) of aziridinium ions by halides.