ChemInform Abstract: Synthetic and Theoretical Investigation on the One-Pot Halogenation of β-Amino Alcohols and Nucleophilic Ring Opening of Aziridinium Ions.

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• 作者：Yunwei Chen ; Xiang Sun ; Ningjie Wu ; Jingbai Li ; Shengnan Jin ; Yongliang Zhong ; Zirui Liu ; Andrey Rogachev and Hyun-Soon Chong
• 关键词：intermediates (and their reactions) ; halogenation ; amines (acyclic compounds) ; diastereoselective syntheses ; enantioselective syntheses (incl. cis/trans-isomerism)
• 刊名：ChemInform
• 出版年：2016
• 出版时间：April, 2016
• 年：2016
• 卷：47
• 期：20
• 全文大小：40K
• ISSN：1522-2667

文摘

A variety of optically active secondary N,N-disubstituted β-halo amines are efficiently synthesized from N,N-disubstituted alaninol via formation and ring opening (at the more hindered carbon) of aziridinium ions by halides.