Polyhydric Corrole and Its Gallium Complex: Synthesis, DNA-binding Properties and Photodynamic Activities

详细信息    查看全文

• 作者：Zhenhua Liang ; Haiyang Liu ; Guangbin Jiang ; Jinyan Wen ; Yunjun Liu and Xinyan Xiao
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：October, 2016
• 年：2016
• 卷：34
• 期：10
• 页码：997-1005
• 全文大小：2925K
• ISSN：1614-7065

文摘

A new hydrophilic polyhydric corrole (1) and its Ga(III) complex (1-Ga) were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activity. Singlet oxygen (¹O₂) was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL-7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS-mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity.