A New Molecularly Imprinted Polymer (MIP)-based Electrochemical Sensor for Monitoring Cardiac Troponin I (cTnI) in the Serum

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• 作者：Juanjuan Zuo ; Xiaoyu Zhao ; Xiaocui Ju ; Shue Qiu ; Wenshuai Hu ; Ting Fan and Juankun Zhang
• 刊名：Electroanalysis
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：28
• 期：9
• 页码：2044-2049
• 全文大小：853K
• ISSN：1521-4109

文摘

A novel molecularly imprinted polymer (MIP) sensor for rapid determination of cardiac troponin (cTnI) was established. Since it can bind to the template molecule cTnI specifically, it can be used to detect concentration of cTnI in serum without much sample pretreatment. What's more, the electrochemical signals depend on the concentration of template molecules. The synthetic sensor possesses advantages including simplicity, high specificity, low cost of preparation, good chemical and mechanical properties, sensitive and label-free determination. The synthetic sensor shows good dynamic linearity at concentration range from 0.05 to 5.00 nM. The limit of detection (LOD) was found to be 0.027 nM. The detection time of whole process was within 5 minutes.