Telomere structure and maintenance gene variants and risk of five cancer types

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• 作者：Sara Karami ; Younghun Han ; Mala Pande ; Iona Cheng ; James Rudd ; Brandon L. Pierce ; Ellen L. Nutter ; Fredrick R. Schumacher ; Zsofia Kote-Jarai ; Sara Lindstrom ; John S. Witte ; Shenying Fang ; Jiali Han ; Peter Kraft ; David J. Hunter ; Fengju Song ; Rayjean J. Hung ; James McKay ; Stephen B. Gruber ; Stephen J. Chanock ; Angela Risch ; Hongbing Shen ; Christopher A. Haiman ; Lisa Boardman ; Cornelia M. Ulrich ; Graham Casey ; Ulrike Peters ; Ali Amin Al Olama ; Andrew Berchuck ; Sonja I. Berndt ; Stephane Bezieau ; Paul Brennan ; Hermann Brenner ; Louise Brinton ; Neil Caporaso ; Andrew T. Chan ; Jenny Chang-Claude ; David C. Christiani ; Julie M. Cunningham ; Douglas Easton ; Rosalind A. Eeles ; Timothy Eisen ; Manish Gala ; Steven J. Gallinger ; Simon A. Gayther ; Ellen L. Goode ; Henrik Grö ; nberg ; Brian E. Henderson ; Richard Houlston ; Amit D. Joshi ; Sé ; bastien Kü ; ry ; Mari T. Landi ; Loic Le Marchand ; Kenneth Muir ; Polly A. Newcomb ; Jenny Permuth-Wey ; Paul Pharoah ; Catherine Phelan ; John D. Potter ; Susan J. Ramus ; Harvey Risch ; Joellen Schildkraut ; Martha L. Slattery ; Honglin Song ; Nicolas Wentzensen ; Emily White ; Fredrik Wiklund ; Brent W. Zanke ; Thomas A. Sellers ; Wei Zheng ; Nilanjan Chatterjee ; Christopher I. Amos ; Jennifer A. Doherty and on behalf of GECCO and the GAME-ON Network ; CORECT ; DRIVE ; ELLIPSE ; FOCI ; and TRICL
• 刊名：International Journal of Cancer
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：139
• 期：12
• 页码：2655-2670
• 全文大小：467K
• ISSN：1097-0215

文摘

Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoining CLPTM1L region are associated with risk of multiple cancers. We therefore investigated associations between variants in 22 telomere structure and maintenance gene regions and colorectal, breast, prostate, ovarian, and lung cancer risk. We performed subset-based meta-analyses of 204,993 directly-measured and imputed SNPs among 61,851 cancer cases and 74,457 controls of European descent. Independent associations for SNP minor alleles were identified using sequential conditional analysis (with gene-level p value cutoffs ≤3.08 × 10⁻⁵). Of the thirteen independent SNPs observed to be associated with cancer risk, novel findings were observed for seven loci. Across the DCLRE1B region, rs974494 and rs12144215 were inversely associated with prostate and lung cancers, and colorectal, breast, and prostate cancers, respectively. Across the TERC region, rs75316749 was positively associated with colorectal, breast, ovarian, and lung cancers. Across the DCLRE1B region, rs974404 and rs12144215 were inversely associated with prostate and lung cancers, and colorectal, breast, and prostate cancers, respectively. Near POT1, rs116895242 was inversely associated with colorectal, ovarian, and lung cancers, and RTEL1 rs34978822 was inversely associated with prostate and lung cancers. The complex association patterns in telomere-related genes across cancer types may provide insight into mechanisms through which telomere dysfunction in different tissues influences cancer risk.