Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp. Collected in the Tibet Plateau Region

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• 作者：Kai Wang ; Li Bao ; Ke Ma ; Wei Qi ; Fuhang Song ; Yijian Yao ; Wenbing Yin ; Lixin Zhang ; Ying Huang ; Junjie Han and Hongwei Liu
• 刊名：European Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：2016
• 期：25
• 页码：4338-4346
• 全文大小：1230K
• ISSN：1099-0690

文摘

Five new spirobisnaphthalenes (1–5), one new tetralone derivative (6), and six new lactones (7–12) together with the known compound urnucratin C (13) have been isolated from the solid culture of the cup fungus Plectania sp. The structures of the new compounds were unambiguously elucidated on the basis of one- and two-dimensional NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Compounds 1–6 were found to be active against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus subtilis, and Pseudomonas aeruginosa. In addition, the cytotoxicities of 1–13 were evaluated against the HepG2 and K562 cell lines by using the CCK8 assay. Compounds 1–3 and 13 showed moderate cytotoxicity against HepG2 and K562 with IC₅₀ values in the range 10.7–38.5 µm. This is the first report of secondary metabolites from this cup fungus.