Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway

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• 作者：Bo Jiang ; Ying-Jie Wang ; Hao Wang ; Lu Song ; Chao Huang ; Qing Zhu ; Feng Wu and Wei Zhang
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：2
• 页码：177-194
• 全文大小：2372K
• ISSN：1476-5381

文摘

Depression is a neuropsychiatric disorder accompanied by a decrease in the brain-derived neurotrophic factor (BDNF) signalling cascade in the hippocampus. Fenofibrate is a selective agonist of PPAR-α. In this study, we investigated the antidepressant-like effects of fenofibrate in C57BL/6J mice.