Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway

详细信息    查看全文

• 作者：Ruijie Zhang ; Nana Zhang ; Hai Zhang ; Chunxiao Liu ; Xiaoqing Dong ; Xiaoxue Wang ; Yu Zhu ; Chong Xu ; Lei Liu ; Sijun Yang ; Shile Huang and Long Chen
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：1
• 页码：82-100
• 全文大小：1527K
• ISSN：1476-5381

文摘

Increasing evidence has suggested cadmium (Cd), as an inducer of ROS, is a potential pathogenic factor in human neurodegenerative diseases. Thus, it is important to find effective interventions for Cd-induced oxidative stress in the CNS. Here, we have studied the effects of celastrol, a plant-derived triterpene, on ROS production and cell death in neuronal cells, induced by Cd.