The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation

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• 作者：Mingcheng Huang ; Shan Zeng ; Yaoyao Zou ; Maohua Shi ; Qian Qiu ; Youjun Xiao ; Guoqiang Chen ; Xiuyan Yang ; Liuqin Liang and Hanshi Xu
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：1
• 页码：101-115
• 全文大小：803K
• ISSN：1476-5381

文摘

There is increasing evidence indicating that bromodomain and extra-terminal domain (BET) proteins play a critical role in the regulation of immune and inflammatory responses; however, their contribution to vascular inflammation has not yet been elucidated. In this study, we investigated the effect of inhibiting BET bromodomain on vascular inflammation and the underlying mechanisms.