A comparison of safety and efficacy of cytotoxic versus molecularly targeted drugs in pediatric phase I solid tumor oncology trials

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• 作者：Kathleen Dorris ; Chunyan Liu ; Dandan Li ; Trent R. Hummel ; Xia Wang ; John Perentesis ; Mi-Ok Kim and Maryam Fouladi
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：64
• 期：3
• 全文大小：798K
• ISSN：1545-5017

文摘

Prior reviews of phase I pediatric oncology trials involving primarily cytotoxic agents have reported objective response rates (ORRs) and toxic death rates of 7.9–9.6% and 0.5%, respectively. These data may not reflect safety and efficacy in phase I trials of molecularly targeted (targeted) drugs.