TiO₂-Supported Re as a General and Chemoselective Heterogeneous Catalyst for Hydrogenation of Carboxylic Acids to Alcohols

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• 作者：Dr. Takashi Toyao ; Dr. S. M. A. Hakim Siddiki ; Dr. Abeda S. Touchy ; Wataru Onodera ; Dr. Kenichi Kon ; Dr. Yoshitsugu Morita ; Dr. Takashi Kamachi ; Prof. Dr. Kazunari Yoshizawa and Prof. Dr. Ken-ichi Shimizu
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 23, 2017
• 年：2017
• 卷：23
• 期：5
• 页码：1001-1006
• 全文大小：870K
• ISSN：1521-3765

文摘

TiO₂-supported Re, Re/TiO₂, was found to promote selective hydrogenation of carboxylic acids having aromatic and aliphatic moieties to the corresponding alcohols. Re/TiO₂ showed superior results compared to other transition-metal-loaded TiO₂ and supported Re catalysts for selective hydrogenation of 3-phenylpropionic acid. 3-phenylpropanol was produced in 97 % yield under mild conditions (5 MPa H₂ at 140 °C). Contrary to typical heterogeneous catalysts, Re/TiO₂ does not lead to the formation of dearomatized byproducts. The catalyst is recyclable and shows a wide substrate scope in the synthesis of alcohols (22 examples; up to 97 % isolated yield).