Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

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• 作者：Jianzhong Liu ; Kai Wu ; Tao Shen ; Yujie Liang ; Miancheng Zou ; Yuchao Zhu ; Xinwei Li ; Xinyao Li and Prof. Dr. Ning Jiao
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 12, 2017
• 年：2017
• 卷：23
• 期：3
• 页码：563-567
• 全文大小：1250K
• ISSN：1521-3765

文摘

A novel and efficient Fe-catalyzed direct C−H amination (NH₂) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.