文摘
Back Cover: Aggregation-prone antibody single-chain variable fragments (scFv) are refolded from urea solutions in the presence of amphiphilic derivatives of poly(sodium acrylate) playing the role of artificial chaperons. Weak noncovalent interactions with the polymers impart solubility to partly-folded scFv intermediates, resulting in recovery of the native-like structure. This is reported by Nicolas Martin, Narciso Costa, Frank Wien, Françoise M. Winnik, Céline Ortega, Amaury Herbet, Didier Boquet, and Christophe Tribet, article number 1600213.