Characteristics and Methodological Quality of Meta-Analyses on Hypertension Treatments—A Cross-Sectional Study

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• 作者：Xin Yin Wu ; Xin Jian Du ; Robin S.T. Ho ; Clarence C.Y. Lee ; Benjamin H.K. Yip ; Martin C.S. Wong ; Samuel Y.S. Wong and Vincent C.H. Chung
• 刊名：The Journal of Clinical Hypertension
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：2
• 页码：137-142
• 全文大小：167K
• ISSN：1751-7176

文摘

Methodological quality of meta-analyses on hypertension treatments can affect treatment decision-making. The authors conducted a cross-sectional study to investigate the methodological quality of meta-analyses on hypertension treatments. One hundred and fifty-eight meta-analyses were identified. Overall, methodological quality was unsatisfactory in the following aspects: comprehensive reporting of financial support (1.9%), provision of included and excluded lists of studies (22.8%), inclusion of grey literature (27.2%), and inclusion of protocols (32.9%). The 126 non-Cochrane meta-analyses had poor performance on almost all the methodological items. Non-Cochrane meta-analyses focused on nonpharmacologic treatments were more likely to consider scientific quality of included studies when making conclusions. The 32 Cochrane meta-analyses generally had good methodological quality except for comprehensive reporting of the sources of support. These results highlight the need for cautious interpretation of these meta-analyses, especially among physicians and policy makers when guidelines are formulated. Future meta-analyses should pay attention to improving these methodological aspects.