Sex Difference in the Association Between Brachial Pulse Pressure and Coronary Artery Disease: The Korean Women's Chest Pain Registry (KoROSE)

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• 作者：Hack-Lyoung Kim ; Myung-A Kim ; Wan-Joo Shim ; Sohee Oh ; Mina Kim ; Seong Mi Park ; Yong Hyun Kim ; Jin Oh Na ; Mi Seung Shin ; Hyun Ju Yoon ; Gil Ja Shin ; Yunkyung Cho ; Sung-Eun Kim ; Kyung-Soon Hong and Kyoung Im Cho
• 刊名：The Journal of Clinical Hypertension
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：38-44
• 全文大小：354K
• ISSN：1751-7176

文摘

This study was performed to investigate the association between brachial pulse pressure (PP) and the presence/extent of obstructive coronary artery disease (CAD) in men and women. Study data were obtained from a nation-wide registry composed of 632 patients (173 men and 459 women, 58.1±10.5 years) with suspected CAD who underwent invasive coronary angiography. PP was higher in patients with obstructive CAD (≥50% stenosis) than those without CAD in both sexes (P=.032 in men; P<.001 in women). However, PP increased proportionally with the increasing number of obstructed coronary arteries in women (P<.001) but not in men (P=.070). Multiple logistic-regression analyses demonstrated that higher PP (≥50.5 mm Hg) was an independent factor for determining obstructive CAD even after controlling for potential confounders in women (odds ratio, 2.83; 95% confidence interval, 1.40–5.73; P=.004). These results were consistent in 173 selected women matched with 173 men based on age and CAD severity. In conclusion, the association between brachial PP and obstructive CAD was more pronounced in women than in men. Brachial PP can be a simple and useful indicator of CAD especially in women.