Redox-Neutral Rhodium-Catalyzed [4+1] Annulation through Formal Dehydrogenative Vinylidene Insertion

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• 作者：Huan Liu ; Shengjin Song ; Cheng-Qiang Wang ; Prof. Dr. Chao Feng and Prof. Dr. Teck-Peng Loh
• 刊名：ChemSusChem
• 出版年：2017
• 出版时间：January 10, 2017
• 年：2017
• 卷：10
• 期：1
• 页码：58-61
• 全文大小：938K
• ISSN：1864-564X

文摘

A synthetic protocol for the expedient construction of 5-methylene-1H-pyrrol-2(5H)-one derivatives through rhodium-catalyzed [4+1] annulation with gem-difluoroacrylate as the C₁ component was reported. By taking advantage of the twofold C−F bond cleavage occurring during the annulation, this reaction not only allows the synthesis of these heterocyclic compounds under overall oxidant-free conditions but also renders the transformation stereospecific. The very mild reaction conditions employed ensure compatibility with a wide variety of synthetically useful functional groups.