Role of alpha- and beta-adrenergic receptors in cardiomyocyte differentiation from murine-induced pluripotent stem cells

详细信息    查看全文

• 作者：Xiao-Li Li ; Di Zeng ; Yan Chen ; Lu Ding ; Wen-Ju Li ; Ting Wei ; Dong-Bo Ou ; Song Yan ; Bin Wang and Qiang-Sun Zheng
• 刊名：Cell Proliferation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：1
• 全文大小：1986K
• ISSN：1365-2184

文摘

Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adrenergic receptors (ARs) in stem cells after differentiation; however, roles of ARs in fate specification of stem cells, particularly in cardiomyocyte differentiation and development, have not been characterized.