Rh^III-Catalyzed Regioselective Synthesis of Phthalides with Water as the Solvent

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• 作者：You-Quan Zhu ; Jun-Xian Li ; Ting-Feng Han ; Jing-Li He and Kun Zhu
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：2017
• 期：4
• 页码：806-811
• 全文大小：889K
• ISSN：1099-0690

文摘

Under rhodium(III)-catalyzed conditions, a broad range of benzoic acids reacted with acrylates successfully to provide phthalides through the direct functionalization of a C–H bond followed by β-hydride elimination and intramolecular Michael addition. The reaction provides an alternative strategy for the construction of diverse and useful phthalide derivatives from readily available starting materials. In most cases, high regioselectivity was obtained, and this is the first report of the rhodium-catalyzed synthesis of phthalides in water.