Ti-Catalyzed Synthesis of Exocyclic Allenes on Oxygen Heterocycles

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• 作者：Natalia M. Padial ; Carmen Hern&aacute ; ndez-Cervantes ; Juan Muñ ; oz-Bascó ; n ; Esther Rold&aacute ; n-Molina ; Mireya Garcí ; a-Martí ; nez ; Ana Belé ; n Ruiz-Muelle ; Antonio Rosales ; Mí ; riam &Aacute ; lvarez-Corral ; Manuel Muñ ; oz-Dorado ; Ignacio Rodrí ; guez-Garcí ; a and J. Enrique Oltra
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：2017
• 期：3
• 页码：639-645
• 全文大小：841K
• ISSN：1099-0690

文摘

A general method for the straightforward synthesis of exocyclic allenes on five-, six-, seven-, and eight-membered oxygen heterocycles is described. A Barbier-type titanocene(III)-catalyzed cyclization of propargyl halides with a pendant carbonyl group is the key step of the process. This reaction is compatible with many functional groups, and can be smoothly carried out under neutral and mild conditions at room temperature.