Copper(I)-Catalyzed α-Acryloyloxylation of Ketones with α,β-Unsaturated Carboxylic Acids To Form α-Acryloyloxy Ketones

详细信息    查看全文

• 作者：Jing-Wen Xu ; Peng-Yi Ji ; Yu-Feng Liu ; Wei-Ping Luo ; Qiang Liu and Can-Cheng Guo
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：2017
• 期：3
• 页码：734-740
• 全文大小：1006K
• ISSN：1099-0690

文摘

An efficient method for the α-C–H acryloyloxylation of ketones with α,β-unsaturated carboxylic acids was developed, using copper(I) as a catalyst. The most concise approach to form α-acryloyloxy ketones is through direct oxidative coupling at the α-C(sp³)–H position of ketones. This method gives the products in high yields, and has a wide substrate scope in terms of both ketones and unsaturated carboxylic acids. A copper(I)-catalyzed reaction mechanism is proposed based on the results of control experiments.