2D Materials: Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues (Adv. Mater. 5/2017)

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• 作者：Yun-Han Ma ; Wei-Tao Dou ; Yu-Fei Pan ; Li-Wei Dong ; Ye-Xiong Tan ; Xiao-Peng He ; He Tian and Hong-Yang Wang
• 刊名：Advanced Materials
• 出版年：2017
• 出版时间：February 2, 2017
• 年：2017
• 卷：29
• 期：5
• 全文大小：3082K
• ISSN：1521-4095

文摘

In article 1604253, X.-P. He, H.-Y. Wang, and co-workers describe supramolecular assembly between water-soluble 2D MoS₂ and a peptide probe producing a 2D peptidosheet suited for the profiling of different carcinoma tissues over healthy tissues in clinical specimens. The dragon symbolizes the peptide ligand selective for CD47 on the surface of cancer tissues. The dragon is originally “hidden” in the 2D MoS₂ materials, but once it detects cancer tissues, it is set free to shed light on the cancer, rather than normal tissues without CD47 expression, through releasing its fire (fluorescence).