A Powerful CD8⁺ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant

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• 作者：Zichao Luo ; Qinjie Wu ; Chengbiao Yang ; Huaimin Wang ; Tao He ; Youzhi Wang ; Zhongyan Wang ; Hao Chen ; Xingyi Li ; Changyang Gong and Zhimou Yang
• 刊名：Advanced Materials
• 出版年：2017
• 出版时间：February 2, 2017
• 年：2017
• 卷：29
• 期：5
• 全文大小：3414K
• ISSN：1521-4095

文摘

A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.