Drug Delivery: Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation (Adv. Mater. 4/2017)

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• 作者：Yuqi Zhang ; Jicheng Yu ; Jinqiang Wang ; Nicholas J. Hanne ; Zheng Cui ; Chenggen Qian ; Chao Wang ; Hongliang Xin ; Jacqueline H. Cole ; Caterina M. Gallippi ; Yong Zhu and Zhen Gu
• 刊名：Advanced Materials
• 出版年：2017
• 出版时间：January 25, 2017
• 年：2017
• 卷：29
• 期：4
• 全文大小：3714K
• ISSN：1521-4095

文摘

A thrombin-responsive microneedle-based transcutaneous patch is developed by C. M. Gallippi, Y. Zhu, Z. Gu, and co-workers, as demonstrated in article 1604043. The anticoagulant drug heparin is loaded into the hyaluronic acid needles through a thrombin cleavable peptide linker. This heparin patch can sense the thrombin level in blood vessels and autoregulate blood coagulation in a long-term manner. Cover design credit: Yuqi Zhang.