A comparison of immunohistochemical and molecular methods used for analyzing the BRAF V600E gene mutation in malignant melanoma in Taiwan

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• 作者：Wen-Kuan Huang ; Tseng-Tong Kuo ; Chiao-En Wu ; Hsin-Yi Cheng ; Chia-Hsun Hsieh ; Jia-Juan Hsieh ; Yung-Chi Shen ; Ming-Mo Hou ; Todd Hsu and John Wen-Cheng Chang
• 刊名：Asia-Pacific Journal of Clinical Oncology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：4
• 页码：403-408
• 全文大小：505K
• ISSN：1743-7563

文摘

The BRAF V600 mutation has been shown to be clinically meaningful in terms of both the prognosis and sensitivity of BRAF inhibitors in patients with metastatic melanoma. Recently, a BRAF V600E mutation-specific antibody, VE1, was generated for the detection of tumors bearing BRAF V600E mutations. To determine the clinical value of immunohistochemical testing, we compared the prevalence of mutant BRAF detected by VE1 with direct sequencing results.