An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

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• 作者：Feng-Pai Chou ; Chia-Tse Tsai ; Ya-Sheng Chiou ; Yi-Ju Chen ; Meng-Erh Li ; Ting-Wei Guo ; Jason WenJay Lyu ; Sheng-Hao Chou and Tung-Kung Wu
• 刊名：Chemical Biology & Drug Design
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：89
• 期：1
• 页码：61-66
• 全文大小：752K
• ISSN：1747-0285

文摘

Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.