Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model

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• 作者：Bing Zhang ; Jia-Wei Zhang ; Wei-Ping Wang ; Rui-Fang Dong ; Shuang Tian and Chao Zhang
• 刊名：Synapse
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：71
• 期：2
• 全文大小：505K
• ISSN：1098-2396

文摘

Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that is widely used in clinic. However, the effect of LTG on cognition and neurodegeneration during epilepsy treatment remains controversial. In this study, we compared the cognitive effects of LTG and sodium valproate in pentylenetetrazole (PTZ)-kindled animal model, and the dose dependency was tested for LTG.