Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury

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• 作者：Hui Liu ; Qian Li ; Ying Wang ; Huimin Hong ; Mengting Chen ; Yingyi Wang ; Fenfang Hong and Shulong Yang
• 刊名：Hepatology Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：47
• 期：2
• 页码：178-185
• 全文大小：193K
• ISSN：1872-034X

文摘

Hepatic injury is a major event in liver surgery such as liver transplantation and it always leads to hepatic cell apoptosis. Nitric oxide (NO) is a key signaling regulation molecule. Many researchers have shown that increased NO level can influence liver cell apoptosis by promoting or inhibiting the relative signaling pathways that are involved in the caspase family, Bax/Bcl-2, mitochondria, oxidative stress, death receptors, and mitogen-activated protein kinases. Elucidating the relationships between NO and hepatic cell apoptosis is necessary for ameliorating prognosis of liver surgery. This article reviews the newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury.