Remote ischemic conditioning protects against acetaminophen-induced acute liver injury in mice

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• 作者：Wei Zheng ; Zhiyong Zhang ; Sushun Liu ; Jianbin Bi ; Jingyao Zhang ; Lixue Du ; Xiaoming Ding and Chang Liu
• 刊名：Hepatology Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：47
• 期：2
• 页码：234-245
• 全文大小：1225K
• ISSN：1872-034X

文摘

Acetaminophen (APAP) overdose is a major cause of drug-induced acute liver failure. Studies have shown that remote ischemic pre- and post-conditioning (R-IPC and R-IPOST) can protect the liver against ischemia–reperfusion (I/R) and lipopolysaccharide-induced injuries. The aim of this study was to investigate the effect of R-IPC and R-IPOST on APAP-induced hepatotoxicity in mice.