Dysregulation of MicroRNA-543 expression in colorectal cancer promotes tumor migration and invasion

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• 作者：Jian Sun ; Jianping Zhou ; Ming Dong and Weiwei Sheng
• 刊名：Molecular Carcinogenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：56
• 期：1
• 页码：250-257
• 全文大小：3977K
• ISSN：1098-2744

文摘

MicroRNAs (miRNAs) have been proven to act as key post-transcriptional regulators of gene expression, involved in the genesis and development of multiple tumor types. However, the expression and roles of miR-543 in colorectal cancer (CRC) remain unknown. Here, we found that miR-543 was constitutively up-regulated in CRC tissues and its over-expression promoted tumor cell migration and invasion. Moreover, we identified PTEN as a direct target of miR-543 using subsequent software analysis and a dual-luciferase reporter assay. In conclusion, data presented here demonstrate that miR-543 acts as a tumor promoter and plays a vital role in CRC metastasis. These findings confirm that miR-543 may potentially serve as a novel therapeutic target for treating CRC.