8-C-(E-phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation

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• 作者：Yueliang Zhao ; Daming Fan ; Zong-Ping Zheng ; Edmund T.S. Li ; Feng Chen ; Ka-Wing Cheng and Mingfu Wang
• 刊名：Molecular Nutrition & Food Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：2
• 全文大小：2061K
• ISSN：1613-4133

文摘

Quercetin, a flavonoid, widely distributed in edible fruits and vegetables, was reported to effectively inhibit 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) formation in a food model (roast beef patties) with itself being converted into a novel compound 8-C-(E-phenylethenyl)quercetin (8-CEPQ). Here we investigated whether 8-CEPQ could be formed in a real food system, and tested its anticancer activity in human colon cancer cell lines.