Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release

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• 作者：Lilong Gao ; Qiang Sun ; Ying Wang ; Weipu Zhu ; Xiaojun Li ; Qiaojie Luo ; Xiaodong Li and Zhiquan Shen
• 刊名：Polymers for Advanced Technologies
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：35-40
• 全文大小：352K
• ISSN：1099-1581

文摘

Water-soluble poly(ethylene glycol) derivatives with multiple “clickable” mercapto groups or double bonds were facilely synthesized in a large scale by direct polycondensation of oligo(ethylene glycol) diol with mercaptosuccinic acid or maleic acid catalyzed by scandium trifluoromethanesulfonate under mild conditions. Injectable hydrogels containing doxorubicin hydrochloride (DOX · HCl) could be rapidly formed using these poly(ethylene glycol) derivatives as precursors via in situ thiol-ene “click” reaction under physiological conditions without light, initiator, or metal catalyst. DOX · HCl could be sustained released from the hydrogels as a result of the hindrance of the three dimensional hydrogel network on the drug molecules, which makes this kind of DOX-loaded hydrogels a promising candidate for localized tumor chemotherapy. Copyright