Enantioselective NiH/Pmrox-Catalyzed 1,2-Reduction of α,β-Unsaturated Ketones

详细信息    查看全文

• 作者：Fenglin Chen ; Yao Zhang ; Prof. Dr. Lei Yu and Prof. Dr. Shaolin Zhu
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：February 13, 2017
• 年：2017
• 卷：56
• 期：8
• 页码：2022-2025
• 全文大小：830K
• ISSN：1521-3773

文摘

The enantioselective 1,2-reduction of α,β-unsaturated ketones was achieved using a NiH catalyst in the presence of pinacolborane. This mild process represents a general method to access a wide variety of structurally diverse α-chiral allylic alcohols in excellent yields and enantioselectivity, as well as very high levels of ambidoselectivity for 1,2- over 1,4-reduction. Furthermore, for reactions on a 10 mmol scale, catalyst loadings as low as 0.5 mol % could be employed to deliver product without any detrimental effect on the yield, enantio-, or ambidoselectivity.