Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes

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• 作者：Xingliang Nie ; Prof. Cungui Cheng and Prof. Dr. Gangguo Zhu
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：February 6, 2017
• 年：2017
• 卷：56
• 期：7
• 页码：1898-1902
• 全文大小：880K
• ISSN：1521-3773

文摘

A palladium-catalyzed three-component reaction between fluoroalkyl bromides, arylboronic acids, and alkenyl aldehydes has been developed and provides facile access to 5-, 6-, or 7-difluoroalkylated ketones under very mild reaction conditions. The resultant products can be smoothly converted into CF₂-containing tetrahydronaphthalenes by a novel silver-catalyzed intramolecular decarboxylative cyclization of 5-aryl-2,2-difluoropentanoic acids.