Photoswitchable and Water-Soluble Fluorescent Nano-Aggregates Based on a Diarylethene-Dansyl Dyad and Liposome

详细信息    查看全文

• 作者：Prof. Hongbo Cheng ; Dr. Pin Ma ; Dr. Yanan Wang ; Dr. Guofei Hu ; Prof. Shibi Fang ; Prof. Yanyan Fang and Prof. Yuan Lin
• 刊名：Chemistry – An Asian Journal
• 出版年：2017
• 出版时间：January 17, 2017
• 年：2017
• 卷：12
• 期：2
• 页码：248-253
• 全文大小：1395K
• ISSN：1861-471X

文摘

In this work, a unique approach is developed to generate photoswitchable and water-soluble fluorescent nano-aggregates. Initially, a new light-controlled diarylethene–dansyl dyad DAE 1 is formed by linking two dansyl fluorophores covalently to a symmetrical dithienylethene backbone, whose photophysical properties can be reversibly switched by optical stimuli. Subsequently, the water insolubility of the molecular switch 1 is overcome by incorporating it into the bilayer of liposome DPPC (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) in water. This strategy creates stable fluorescent nano-aggregates OF-1@DPPC (≈25 nm diameter) that are soluble in an aqueous medium. The nano-aggregates OF-1@DPPC retain and even improve the photoswitchable fluorescence properties of DAE 1. More importantly, OF-1@DPPC exhibits a remarkable photostability and fatigue resistance after 5 cycles of irradiation with UV and visible light, which is crucial for its practical application.