Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs

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• 作者：Karolina Ploj ; Lambertus Benthem ; Dorota Kakol-Palm ; Peter Gennemark ; Liselotte Andersson ; Mikael Bjursell ; Jenny Bö ; rjesson ; Lillevi Krrberg ; Marianne Må ; nsson ; Madeleine Antonsson ; Anders Johansson ; Suzanne Iverson ; Bjö ; rn Carlsson ; Andrew Turnbull and Daniel Lindé ; n
• 刊名：British Journal of Pharmacology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：173
• 期：18
• 页码：2739-2751
• 全文大小：1179K
• ISSN：1476-5381

文摘

Melanin-concentrating hormone (MCH) is an orexigen, and while rodents express one MCH receptor (MCH₁ receptor), humans, non-human primates and dogs express two MCH receptors (MCH₁ and MCH₂). MCH₁ receptor antagonists have been developed for the treatment of obesity and lower body weight in rodents. However, the mechanisms for the body weight loss and whether MCH₁ receptor antagonism can lower body weight in species expressing both MCH receptors are not fully understood.